
Giardia lamblia is a flagellate protozoan parasite that can be found
in the intestinal tract of humans and most domestic animals. Giardia can cause
protracted intermittent diarrhea in some individuals but can exist as a latent
infection (present but not causiong symptoms) in others.
Giardia can affect
humans and most domestic animals. Younger animals may be more susceptible.
Immunodeficient adults, young animals and animals confined in large groups are
at increased risk. Giardia does not appear to be highly host specific; spread
of infection from dogs and cats to people should be considered possible. Most
infections produce no clinical signs. But if diarrhea results, it can be acute
and short lived, intermittent or chronic. Fatty stools or weight loss may be
observed. Vomiting, fever and anorexia may occur but are not typical. Signs
consistent with either acute or chronic large bowel diarrhea occur in cats. A
physical exam may show no significant abnormalities.
The giardia life
cycle is direct. Cysts are ingested and excyst in the duodenum, each cyst
producing two motile trophozites that replicate within the wall of the small
intestine. Before being shed in feces, the trophozite encysts. On excretion,
the cysts are infective to another host. Cysts can survive for days to weeks in
a cool, moist environment. Trophozoites are thought to cause sloughing of
intestinal epithelial cells, resulting in blunting of the intestinal villi and
subsequent reduction in absorptive surface area causing malabsorption and
diarrhea. Abnormalities in the immune system likely predispose individuals to
clinical infection. Immunosuppressive drugs may predispose to clinical
infection.
Giardia vaccination
has not been shown to be an effective treatment of an infected individual. We
use the vaccine to reduce the shedding of cysts, which in turn reduces the
probability of contamination and passing it to other animals or people.. Many
individuals may be cured with prompt diagnosis and appropriate treatment, but
recurrent infections are well documented. The most effective treatment at
this time is the use of fenbendozole (Panacur) on a daily basis for 5-6 days in
a row. It has recently been stated in the literature that the concurrent use of
a probiotic, (Gastromate, Probiosin) may improve the effectiveness of the
Fenbendozole treatment. It is also recommended to bath the affected animals to
eleminate any cysts that are attached to the hair coat. Thoroughly drying any
areas, like outside runs, where the animals are kept would also be beneficial.